LRP8

Across TCGA patient cohorts, LRP8 mutation is significantly associated with the RNA expression of many other genes, with 1,740 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP8-associated genes across cancer lineages are EIF4E, HSPA4L, and CHAF1A. Each is linked with LRP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP8-to-partner and partner-to-LRP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4E grouped by LRP8-low versus LRP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP8→partner) and Y-score (partner→LRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF4E →	+0.379	+3.480	.004	.002	3	3
UCEC	HSPA4L →	+0.653	+3.016	.001	<.001	3	3
UCEC	CHAF1A →	+0.638	+3.130	<.001	<.001	3	3
UCEC	LETM1 →	+0.547	+2.502	<.001	<.001	3	3
UCEC	NIPA1 →	+0.792	+3.087	<.001	<.001	3	3
UCEC	RRM2 →	+0.913	+2.914	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,740 associations by consensus.

EIF4E by LRP8 expression — UCEC

Explore this box plot interactively →