LRP8

Across TCGA cell cohorts, LRP8 mutation is significantly associated with the RNA expression of many other genes, with 1,139 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRP8-associated genes across cancer lineages are CCR8, NLRP8, and SUPT20HL1. Each is linked with LRP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP8-to-partner and partner-to-LRP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by LRP8-low versus LRP8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP8→partner) and Y-score (partner→LRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
OVARY	NLRP8 →	+0.006	+5.196	<.001	.005	3	1
OVARY	SUPT20HL1 →	+0.123	+5.807	<.001	.001	3	1
BLOOD_Lymphoma	FCN2 →	+0.048	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	ZNF804B →	+0.013	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	FABP12 →	+0.071	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,139 associations by consensus.

CCR8 by LRP8 expression — SOFT_TISSUE

Explore this box plot interactively →