LRP5

Across TCGA pan-cancer cohorts, LRP5 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated LRP5 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LRP5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LRP5 expression acts as an unfavorable survival marker.

PDAC and LUAD are the cancer types where LRP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.381	0.823	.036	6	view →
LUAD	DFS	Median	II,III,IV	0.279	0.761	.010	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

LRP5–PDAC (OS)

Open the PDAC breakdown →