LRP3

Across TCGA patient cohorts, LRP3 protein abundance is significantly associated with the RNA expression of many other genes, with 707 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LRP3-associated genes across cancer lineages are KLF8, MEF2D, and NTPCR. Each is linked with LRP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP3-to-partner and partner-to-LRP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRP3 versus KLF8 in BRCA, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP3→partner) and Y-score (partner→LRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KLF8 →	+1.592	+1.032	.006	.003	3	1
BRCA	MEF2D →	+0.857	+1.032	.009	.003	3	1
BRCA	NTPCR →	+0.737	+1.032	<.001	.003	3	1
BRCA	ALDH9A1 →	+1.267	+1.032	.003	.003	3	1
BRCA	RRNAD1 →	+0.986	+0.870	.001	<.001	3	1
BRCA	SRP9 →	+1.037	+1.032	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 707 associations by consensus.

LRP3 vs KLF8 — BRCA

Explore this scatter interactively →