LRP3

Across TCGA patient cohorts, LRP3 mutation is significantly associated with the RNA expression of many other genes, with 3,449 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP3-associated genes across cancer lineages are CFTR, STOML2, and ESCO2. Each is linked with LRP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP3-to-partner and partner-to-LRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFTR grouped by LRP3-low versus LRP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP3→partner) and Y-score (partner→LRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CFTR →	-1.169	-3.668	.001	.001	3	3
UCEC	STOML2 →	+0.453	+3.740	.002	<.001	3	3
UCEC	ESCO2 →	+0.604	+2.230	.002	.006	3	3
UCEC	FUT10 →	+0.631	+2.736	<.001	<.001	3	3
LUSC	RNF10P1 →	+0.109	+2.847	<.001	.002	3	3
COAD	RN7SL74P →	+0.316	+3.061	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,449 associations by consensus.

CFTR by LRP3 expression — UCEC

Explore this box plot interactively →