LRP3

Across TCGA patient cohorts, LRP3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP3-associated genes across cancer lineages are Ku80, Notch1, and PCNA. Each is linked with LRP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP3-to-partner and partner-to-LRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by LRP3-low versus LRP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP3→partner) and Y-score (partner→LRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.305	+3.183	.001	.009	3	2
UCEC	Notch1 →	+0.215	+2.335	<.001	.018	3	2
UCEC	PCNA →	+0.223	+1.807	.012	.027	3	2
UCEC	ATM →	-0.634	-3.000	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.702	+2.341	.004	.019	3	2
COAD	INPP4B →	-0.381	-2.991	.049	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Ku80 by LRP3 expression — UCEC

Explore this box plot interactively →