LRP2BP

Across TCGA patient cohorts, LRP2BP mutation is significantly associated with the RNA expression of many other genes, with 1,762 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP2BP-associated genes across cancer lineages are RNU6-706P, RNU6-1022P, and RNA5SP55. Each is linked with LRP2BP in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP2BP-to-partner and partner-to-LRP2BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-706P grouped by LRP2BP-low versus LRP2BP-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP2BP→partner) and Y-score (partner→LRP2BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-706P →	+0.263	+7.954	<.001	.008	3	2
LUSC	RNU6-1022P →	+0.458	+7.924	<.001	.008	3	2
SKCM	RNA5SP55 →	+0.318	+6.797	<.001	<.001	3	2
UCEC	MIR6803 →	+0.119	+4.086	<.001	.005	3	2
UCEC	RNA5SP451 →	+0.163	+2.604	.008	.005	3	2
UCEC	RNA5SP416 →	+0.396	+2.031	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,762 associations by consensus.

RNU6-706P by LRP2BP expression — HNSC

Explore this box plot interactively →