LRP2BP

Across TCGA patient cohorts, LRP2BP mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP2BP-associated genes across cancer lineages are eIF4E, ERK2, and Shc_pY317. Each is linked with LRP2BP in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP2BP-to-partner and partner-to-LRP2BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LRP2BP-low versus LRP2BP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP2BP→partner) and Y-score (partner→LRP2BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.186	+1.847	.016	.008	3	2
UCEC	ERK2 →	+0.194	+2.700	.006	.006	3	2
UCEC	Shc_pY317 →	-0.133	-1.502	.017	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.787	+2.827	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.141	-2.723	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.248	-2.247	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eIF4E by LRP2BP expression — UCEC

Explore this box plot interactively →