LRP2BP

Across TCGA cell cohorts, LRP2BP mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LRP2BP-associated genes across cancer lineages are TAFA1, OR10W1, and PNMA6F. Each is linked with LRP2BP in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP2BP-to-partner and partner-to-LRP2BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by LRP2BP-low versus LRP2BP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP2BP→partner) and Y-score (partner→LRP2BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
BREAST	OR10W1 →	+0.010	+4.781	<.001	.003	3	1
BREAST	PNMA6F →	+0.039	+5.312	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TAFA1 by LRP2BP expression — LARGE_INTESTINE

Explore this box plot interactively →