LRP1B

Across TCGA pan-cancer cohorts, LRP1B Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated LRP1B data layer compared with 26 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher LRP1B Mutation is associated with better overall survival. In most high-consensus cancer types, elevated LRP1B expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, UCEC, and SCLC are the cancer types where LRP1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.705	0.388	.003	31	view →
UCEC	DFS	Median	II,III,IV	0.867	0.297	.008	28	view →
SCLC	DFS	Median	All	1.000	0.593	.002	19	view →
LIHC	OS	Median	III,IV	0.192	0.567	<.001	17	view →
KIRP	OS	Median	All	0.157	0.692	.008	16	view →
SKCM	OS	Median	All	0.926	0.831	.001	15	view →
ESCA	OS	Median	II,III,IV	0.330	1.000	<.001	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
CESC	OS	Median	III,IV	0.393	0.791	.002	8	view →
STAD	OS	Median	IV	0.711	0.243	.012	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
UCS	DFS	Median	All	1.000	0.394	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

LRP1B–BLCA (OS)

Open the BLCA breakdown →