LRP12

Across TCGA patient cohorts, LRP12 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP12-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and JNK2. Each is linked with LRP12 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRP12-to-partner and partner-to-LRP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LRP12-low versus LRP12-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP12→partner) and Y-score (partner→LRP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.196	+2.321	.016	.034	3	4
UCEC	FOXO3a_pS318_S321 →	-0.103	-1.513	.005	.006	3	3
UCEC	JNK2 →	+0.221	+1.807	<.001	<.001	3	3
UCEC	Ku80 →	+0.218	+1.598	.001	.001	3	3
STAD	TFRC →	+0.581	+2.321	.039	.034	3	2
STAD	YAP_pS127 →	-0.365	-2.321	.012	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

eIF4E by LRP12 expression — STAD

Explore this box plot interactively →