LRP12

Across TCGA cell cohorts, LRP12 mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRP12-associated genes across cancer lineages are MAD2L1, PPP1CC, and GML. Each is linked with LRP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRP12-to-partner and partner-to-LRP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAD2L1 grouped by LRP12-low versus LRP12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP12→partner) and Y-score (partner→LRP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAD2L1 →	+0.606	+3.064	.007	.009	3	2
LARGE_INTESTINE	PPP1CC →	+0.408	+3.364	.004	.002	3	2
STOMACH	GML →	+0.032	+4.285	<.001	.007	3	1
STOMACH	OR5H2 →	+0.207	+4.285	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	GYPB →	+0.150	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	KCNK16 →	+0.041	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

MAD2L1 by LRP12 expression — LARGE_INTESTINE

Explore this box plot interactively →