Across TCGA patient cohorts, LRP10 mutation is significantly associated with the RNA expression of many other genes, with 3,157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP10-associated genes across cancer lineages are SKA2, CDCA2, and MPPE1. Each is linked with LRP10 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP10-to-partner and partner-to-LRP10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP10→partner) and Y-score (partner→LRP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA2 →	+0.579	+3.534	.001	<.001	3	3
UCEC	CDCA2 →	+0.859	+2.874	<.001	<.001	3	3
UCEC	MPPE1 →	+0.443	+2.329	.001	.003	3	3
UCEC	C4orf46 →	+0.635	+2.021	<.001	.001	3	3
UCEC	CDC25A →	+0.523	+2.392	.007	<.001	3	3
UCEC	ANXA5 →	+0.396	+1.673	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,157 associations by consensus.

Exploration

LRP10 survival (RNA) · tumor vs normal (RNA) · all LRP10 data types