LRMDA

Across TCGA patient cohorts, LRMDA mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRMDA-associated genes across cancer lineages are FOXO3a_pS318_S321, p38-MAPK_pT180_Y182, and ATM. Each is linked with LRMDA in more than 1 cancer types. Because this analysis shows association rather than direction, both LRMDA-to-partner and partner-to-LRMDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by LRMDA-low versus LRMDA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRMDA→partner) and Y-score (partner→LRMDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.156	-2.999	.031	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.594	-3.000	.022	.036	3	1
UCEC	ATM →	-0.717	-3.000	.006	.037	3	1
UCEC	Ku80 →	+0.440	+3.013	.001	.019	2	1
UCEC	C-Raf_pS338 →	-0.145	-3.000	.002	.037	2	1
UCEC	eIF4E →	+0.254	+3.000	.037	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a_pS318_S321 by LRMDA expression — UCEC

Explore this box plot interactively →