Across TCGA patient cohorts, LRIT3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRIT3-associated genes across cancer lineages are TIGAR, NF-kB-p65_pS536, and 4E-BP1. Each is linked with LRIT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRIT3-to-partner and partner-to-LRIT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIT3→partner) and Y-score (partner→LRIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.195	+2.222	<.001	.010	3	3
UCEC	NF-kB-p65_pS536 →	-0.333	-2.321	.046	.033	3	2
UCEC	4E-BP1 →	+0.264	+3.459	.007	.005	3	2
UCEC	A-Raf_pS299 →	-0.096	-1.502	.028	.030	3	1
UCEC	ERK2 →	+0.158	+2.222	.025	.010	3	1
UCEC	INPP4B →	-0.255	-2.459	.032	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

LRIT3 survival (RNA) · tumor vs normal (RNA) · all LRIT3 data types