Across TCGA cell cohorts, LRIT3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRIT3-associated genes across cancer lineages are AADACL3, KRTAP2-2, and MS4A4A. Each is linked with LRIT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRIT3-to-partner and partner-to-LRIT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIT3→partner) and Y-score (partner→LRIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	AADACL3 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	KRTAP2-2 →	+0.083	+5.614	<.001	.002	3	1
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.050	+2.994	<.001	.006	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

LRIT3 survival (RNA) · tumor vs normal (RNA) · all LRIT3 data types