LRIT1

Across TCGA cell cohorts, LRIT1 mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRIT1-associated genes across cancer lineages are GAGE12H, ODF1, and GAGE12D. Each is linked with LRIT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRIT1-to-partner and partner-to-LRIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12H grouped by LRIT1-low versus LRIT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIT1→partner) and Y-score (partner→LRIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GAGE12H →	+0.947	+4.922	<.001	.009	3	3
SKIN	ODF1 →	+0.013	+4.022	<.001	.006	3	2
LUNG_NSCLC_LUAD	GAGE12D →	+1.535	+3.491	<.001	.002	3	2
LUNG_NSCLC_LUAD	GAGE12C →	+1.055	+3.491	<.001	.002	3	2
OESOPHAGUS	MMP27 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	ZIM3 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

GAGE12H by LRIT1 expression — BLOOD_Leukemia

Explore this box plot interactively →