LRIG3

Across TCGA patient cohorts, LRIG3 mutation is significantly associated with the RNA expression of many other genes, with 2,329 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRIG3-associated genes across cancer lineages are RNA5SP198, KCTD9, and HSPA9. Each is linked with LRIG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRIG3-to-partner and partner-to-LRIG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by LRIG3-low versus LRIG3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIG3→partner) and Y-score (partner→LRIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP198 →	+0.403	+6.729	<.001	<.001	3	3
UCEC	KCTD9 →	+0.487	+2.684	<.001	<.001	3	3
UCEC	HSPA9 →	+0.345	+1.839	.002	.002	3	3
LUSC	PRR23D1 →	+0.029	+5.008	<.001	.002	3	3
GBM	AGGF1P8 →	+0.074	+5.584	.004	.003	3	2
READ	PGBD4P2 →	+0.096	+4.672	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,329 associations by consensus.

RNA5SP198 by LRIG3 expression — CESC

Explore this box plot interactively →