LRIG3

Across TCGA patient cohorts, LRIG3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRIG3-associated genes across cancer lineages are 4E-BP1, Snail, and 14-3-3_beta. Each is linked with LRIG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRIG3-to-partner and partner-to-LRIG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by LRIG3-low versus LRIG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIG3→partner) and Y-score (partner→LRIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.309	+3.807	<.001	<.001	3	3
SKCM	Snail →	-0.264	-2.987	.004	.035	3	2
UCEC	14-3-3_beta →	-0.069	-1.651	.022	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.526	+2.090	.003	<.001	3	2
SKCM	Paxillin →	+0.568	+3.000	.010	.035	3	1
UCEC	eIF4E →	+0.164	+2.713	.010	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

4E-BP1 by LRIG3 expression — UCEC

Explore this box plot interactively →