LRIG3

Across TCGA cell cohorts, LRIG3 mutation is significantly associated with the RNA expression of many other genes, with 98 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRIG3-associated genes across cancer lineages are DSCAM, OR6C70, and MINAR2. Each is linked with LRIG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRIG3-to-partner and partner-to-LRIG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCAM grouped by LRIG3-low versus LRIG3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIG3→partner) and Y-score (partner→LRIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DSCAM →	+0.062	+3.000	<.001	<.001	3	2
PANCREAS	OR6C70 →	+0.049	+5.000	<.001	.006	3	1
PANCREAS	MINAR2 →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	SMIM9 →	+0.036	+5.614	<.001	.002	3	1
PANCREAS	TP53TG3E →	+0.019	+5.000	<.001	.006	3	1
BLOOD_Leukemia	PIP →	+0.124	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

DSCAM by LRIG3 expression — LARGE_INTESTINE

Explore this box plot interactively →