Across TCGA cell cohorts, LRIG2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LRIG2-associated genes across cancer lineages are WNT8A, TAS1R2, and PRLHR. Each is linked with LRIG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRIG2-to-partner and partner-to-LRIG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIG2→partner) and Y-score (partner→LRIG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WNT8A →	+0.039	+4.217	<.001	.001	3	2
BREAST	TAS1R2 →	+0.014	+4.199	<.001	.007	3	2
SKIN	PRLHR →	+0.015	+5.022	<.001	.002	3	1
SKIN	GPR31 →	+0.004	+4.415	<.001	.007	3	1
SKIN	SCGB2A1 →	+0.093	+4.415	<.001	.007	3	1
SKIN	IL9 →	+0.037	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

LRIG2 survival (RNA) · tumor vs normal (RNA) · all LRIG2 data types