LRIG2-DT

Across TCGA pan-cancer cohorts, LRIG2-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated LRIG2-DT data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRIG2-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRIG2-DT expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

UCEC, LAML, and BRCA are the cancer types where LRIG2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.789	0.895	.001	46	view →
LAML	DFS	Median	All	0.478	0.652	.006	26	view →
BRCA	OS	Median	All	0.945	0.901	.001	24	view →
LGG	OS	Tertile	All	0.946	0.815	<.001	21	view →
KIRC	DFS	Median	All	0.569	0.666	.017	20	view →
KIRP	DFS	Median	All	0.796	0.903	.006	17	view →
COAD	DFS	Median	All	0.442	0.606	.015	12	view →
LUAD	OS	Median	III,IV	0.730	0.578	.016	12	view →
MESO	DFS	Tertile	II,III,IV	0.318	0.794	.019	12	view →
LUSC	DFS	Tertile	II,III,IV	0.320	0.517	.014	10	view →
UCS	DFS	Tertile	II,III,IV	0.542	0.150	.024	8	view →
ACC	OS	Tertile	III,IV	0.785	0.203	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

LRIG2-DT–UCEC (DFS)

Open the UCEC breakdown →