LRGUK

Across TCGA patient cohorts, LRGUK mutation is significantly associated with the RNA expression of many other genes, with 3,340 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRGUK-associated genes across cancer lineages are PSMB6, NPLP1, and CENPM. Each is linked with LRGUK in more than 3 cancer types. Because this analysis shows association rather than direction, both LRGUK-to-partner and partner-to-LRGUK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB6 grouped by LRGUK-low versus LRGUK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRGUK→partner) and Y-score (partner→LRGUK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMB6 →	+0.400	+2.713	.005	.003	3	4
UCEC	NPLP1 →	+0.119	+1.638	.002	<.001	3	3
UCEC	CENPM →	+0.421	+1.485	.006	.003	3	3
UCEC	MCM5 →	+0.455	+3.108	.001	<.001	3	3
COAD	GOT1 →	+0.431	+3.335	.004	.005	3	3
UCEC	TNFSF9 →	+0.790	+2.467	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,340 associations by consensus.

PSMB6 by LRGUK expression — COAD

Explore this box plot interactively →