LRGUK

Across TCGA patient cohorts, LRGUK mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRGUK-associated genes across cancer lineages are eIF4E, ATM, and Caspase-7-cleavedD198. Each is linked with LRGUK in more than 2 cancer types. Because this analysis shows association rather than direction, both LRGUK-to-partner and partner-to-LRGUK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LRGUK-low versus LRGUK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRGUK→partner) and Y-score (partner→LRGUK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.232	+4.013	<.001	<.001	3	3
UCEC	ATM →	-0.621	-2.986	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.093	+2.584	<.001	.010	3	3
UCEC	FOXO3a_pS318_S321 →	-0.126	-2.127	.001	<.001	3	2
COAD	GAPDH →	+0.496	+2.008	.015	.018	3	2
COAD	ACC1 →	+0.339	+1.874	.033	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eIF4E by LRGUK expression — UCEC

Explore this box plot interactively →