LRGUK

Across TCGA cell cohorts, LRGUK mutation is significantly associated with the RNA expression of many other genes, with 918 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRGUK-associated genes across cancer lineages are GCAT, ANKRD54, and EIF3L. Each is linked with LRGUK in more than 1 cancer types. Because this analysis shows association rather than direction, both LRGUK-to-partner and partner-to-LRGUK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by LRGUK-low versus LRGUK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRGUK→partner) and Y-score (partner→LRGUK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.288	+2.850	<.001	<.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.417	+2.936	.005	<.001	3	1
LARGE_INTESTINE	EIF3L →	+0.505	+2.158	.001	.004	3	1
LARGE_INTESTINE	CCDC134 →	+0.602	+2.005	.005	.008	3	1
LARGE_INTESTINE	DEPDC5 →	+0.508	+2.158	.003	.004	3	1
LARGE_INTESTINE	HSCB →	+0.468	+2.158	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 918 associations by consensus.

GCAT by LRGUK expression — LARGE_INTESTINE

Explore this box plot interactively →