LRGUK

Across TCGA cell cohorts, LRGUK mutation is significantly associated with the mutation status of many other genes, with 4,393 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRGUK-associated genes across cancer lineages are KIAA1614, PXDN, and ITGA10. Each is linked with LRGUK in more than 4 cancer types. Because this analysis shows association rather than direction, both LRGUK-to-partner and partner-to-LRGUK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIAA1614 grouped by LRGUK-low versus LRGUK-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRGUK→partner) and Y-score (partner→LRGUK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KIAA1614 →	+5.392	+4.824	.004	.004	1	5
OVARY	PXDN →	+3.047	+4.510	.001	.001	1	5
OVARY	ITGA10 →	+3.047	+4.510	.001	.001	1	5
BREAST	MXRA5 →	+4.297	+4.857	.009	.009	1	5
LARGE_INTESTINE	ATXN7 →	+2.584	+1.999	<.001	<.001	1	5
OVARY	COL16A1 →	+3.632	+4.882	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,393 associations by consensus.

KIAA1614 by LRGUK expression — SKIN

Explore this box plot interactively →