LRG1

Across TCGA pan-cancer cohorts, LRG1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LRG1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRG1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRG1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where LRG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.480	0.946	.003	42	view →
CCRCC	DFS	Tertile	II,III,IV	0.146	0.981	.008	26	view →
LUAD	DFS	Quartile	III,IV	0.253	0.899	<.001	22	view →
COAD	DFS	Tertile	All	0.858	1.000	.030	12	view →
PDAC	DFS	Median	III,IV	0.522	0.849	.012	8	view →
LSCC	DFS	Quartile	II,III,IV	0.830	1.000	.018	6	view →
GBM	DFS	Median	All	0.426	0.221	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LRG1–UCEC (DFS)

Open the UCEC breakdown →