LRG1

Across TCGA patient cohorts, LRG1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,342 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LRG1-associated genes across cancer lineages are LYVE1, DIPK2B, and SEMA6B. Each is linked with LRG1 in more than 7 cancer types. Because this analysis shows association rather than direction, both LRG1-to-partner and partner-to-LRG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRG1 versus LYVE1 in GBM, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRG1→partner) and Y-score (partner→LRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LYVE1 →	+1.322	+0.670	<.001	<.001	3	8
BRCA	DIPK2B →	+0.700	+0.638	<.001	<.001	3	7
COAD	SEMA6B →	+0.805	+0.774	<.001	<.001	3	7
COAD	MEDAG →	+1.212	+0.795	<.001	<.001	3	6
LSCC	STAB1 →	+0.763	+0.593	<.001	<.001	3	6
COAD	F13A1 →	+1.487	+0.614	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,342 associations by consensus.

LRG1 vs LYVE1 — GBM

Explore this scatter interactively →