LRG1

Across TCGA patient cohorts, LRG1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRG1-associated genes across cancer lineages are Akt_pT308, ACC_pS79, and Tuberin_pT1462. Each is linked with LRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRG1-to-partner and partner-to-LRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by LRG1-low versus LRG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRG1→partner) and Y-score (partner→LRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.816	+3.000	.024	.037	3	2
UCEC	ACC_pS79 →	+0.398	+2.817	.047	.036	3	1
UCEC	Tuberin_pT1462 →	+0.323	+2.817	.015	.036	3	1
UCEC	Tuberin →	+0.400	+3.000	.010	.037	2	1
UCEC	Di-Ras3 →	-0.169	-3.000	.048	.037	2	1
UCEC	ACC1 →	+0.430	+3.000	.040	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Akt_pT308 by LRG1 expression — UCEC

Explore this box plot interactively →