LRG1

Across TCGA cell cohorts, LRG1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRG1-associated genes across cancer lineages are ARMH2 and DNAJB8. Each is linked with LRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRG1-to-partner and partner-to-LRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARMH2 grouped by LRG1-low versus LRG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRG1→partner) and Y-score (partner→LRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARMH2 →	+0.180	+3.345	<.001	.007	3	1
LARGE_INTESTINE	DNAJB8 →	+0.013	+3.584	<.001	.003	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ARMH2 by LRG1 expression — LARGE_INTESTINE

Explore this box plot interactively →