LRFN5

Across TCGA patient cohorts, LRFN5 mutation is significantly associated with the RNA expression of many other genes, with 2,615 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRFN5-associated genes across cancer lineages are PPAT, RAB28P4, and EME1. Each is linked with LRFN5 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRFN5-to-partner and partner-to-LRFN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPAT grouped by LRFN5-low versus LRFN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN5→partner) and Y-score (partner→LRFN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPAT →	+0.378	+1.321	.005	.002	3	4
LGG	RAB28P4 →	+0.056	+4.936	<.001	.005	3	4
UCEC	EME1 →	+0.437	+2.042	<.001	.001	3	4
UCEC	BIRC5 →	+0.559	+2.137	.001	<.001	3	4
UCEC	NIPAL2 →	-0.434	-2.378	<.001	<.001	3	3
UCEC	KCTD9 →	+0.480	+1.480	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,615 associations by consensus.

PPAT by LRFN5 expression — UCEC

Explore this box plot interactively →