LRFN5

Across TCGA patient cohorts, LRFN5 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRFN5-associated genes across cancer lineages are Caspase-7-cleavedD198, Chk1, and Raptor. Each is linked with LRFN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRFN5-to-partner and partner-to-LRFN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LRFN5-low versus LRFN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN5→partner) and Y-score (partner→LRFN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.630	+1.958	<.001	<.001	3	3
LUAD	Chk1 →	+0.287	+3.584	<.001	.002	3	3
LUSC	Raptor →	-0.176	-1.751	.008	.011	3	3
UCEC	ASNS →	+0.425	+1.807	<.001	.003	3	3
UCEC	C-Raf →	+0.161	+1.736	<.001	<.001	3	3
STAD	TIGAR →	+0.411	+2.321	.026	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Caspase-7-cleavedD198 by LRFN5 expression — UCEC

Explore this box plot interactively →