LRFN5

Across TCGA cell cohorts, LRFN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,219 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LRFN5-associated GO terms across cancer lineages are Negative regulation of actin filament polymerization, Positive regulation of termination of RNA polymerase II transcription, and Positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled. Each is linked with LRFN5 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRFN5-to-partner and partner-to-LRFN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin filament polymerization grouped by LRFN5-low versus LRFN5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN5→partner) and Y-score (partner→LRFN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of actin filament polymerization →	-0.127	-1.830	<.001	.004	3	5
BONE	Positive regulation of termination of RNA polymerase II transcription →	+0.120	+1.818	<.001	.001	3	5
BONE	Positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled →	+0.122	+2.008	<.001	<.001	3	5
BONE	Interleukin-13-mediated signaling pathway →	-1.359	-2.212	<.001	<.001	3	5
LUNG_SCLC	Regulation of neuromuscular synaptic transmission →	+1.023	+1.648	.002	.004	3	5
LUNG_SCLC	Positive regulation of neuromuscular synaptic transmission →	+1.023	+1.648	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,219 associations by consensus.

Negative regulation of actin filament polymerization by LRFN5 expression — BONE

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