LRFN4

Across TCGA patient cohorts, LRFN4 protein abundance is significantly associated with the RNA expression of many other genes, with 244 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LRFN4-associated genes across cancer lineages are MTHFD1, BTN2A1, and STC2. Each is linked with LRFN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRFN4-to-partner and partner-to-LRFN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRFN4 versus MTHFD1 in BRCA, with a Pearson correlation of -0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN4→partner) and Y-score (partner→LRFN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTHFD1 →	-0.786	-0.693	.006	.006	3	1
BRCA	BTN2A1 →	-0.793	-0.686	.004	.006	3	1
BRCA	STC2 →	-6.426	-0.693	.001	.006	3	1
BRCA	GNMT →	-2.560	-0.693	.002	.006	3	1
BRCA	GCM1 →	-0.766	-0.693	.001	.006	3	1
BRCA	RNF144B →	-1.059	-0.663	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 244 associations by consensus.

LRFN4 vs MTHFD1 — BRCA

Explore this scatter interactively →