LRFN4

Across TCGA patient cohorts, LRFN4 mutation is significantly associated with the RNA expression of many other genes, with 420 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRFN4-associated genes across cancer lineages are MIR8053, KATNBL1P4, and RN7SL147P. Each is linked with LRFN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRFN4-to-partner and partner-to-LRFN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by LRFN4-low versus LRFN4-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN4→partner) and Y-score (partner→LRFN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	MIR8053 →	+0.377	+5.159	<.001	.007	3	3
BLCA	KATNBL1P4 →	+0.119	+6.018	<.001	.002	3	3
KIRP	RN7SL147P →	+0.106	+5.159	.005	.007	3	2
UCEC	CXCL13 →	+1.875	+2.906	<.001	.002	3	2
UCEC	TOP3A →	+0.410	+3.354	.008	.005	3	2
COAD	RNU6-674P →	+0.181	+4.409	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 420 associations by consensus.

MIR8053 by LRFN4 expression — KIRP

Explore this box plot interactively →