LRFN3

Across TCGA patient cohorts, LRFN3 mutation is significantly associated with the RNA expression of many other genes, with 1,121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRFN3-associated genes across cancer lineages are NDUFA6, LRRC10B, and EIF5A. Each is linked with LRFN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRFN3-to-partner and partner-to-LRFN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA6 grouped by LRFN3-low versus LRFN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN3→partner) and Y-score (partner→LRFN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.459	+2.233	.001	.006	3	3
UCEC	LRRC10B →	-1.727	-4.000	<.001	<.001	3	3
UCEC	EIF5A →	+0.397	+2.906	.005	.002	3	3
UCEC	HNRNPCL3 →	+0.043	+2.319	<.001	.003	3	2
UCEC	CIRBP-AS1 →	+0.756	+3.616	<.001	.001	3	2
HNSC	CXADRP1 →	+0.193	+5.368	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,121 associations by consensus.

NDUFA6 by LRFN3 expression — UCEC

Explore this box plot interactively →