LRFN3

Across TCGA patient cohorts, LRFN3 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRFN3-associated genes across cancer lineages are RAD51, ATM, and ER-alpha_pS118. Each is linked with LRFN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRFN3-to-partner and partner-to-LRFN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by LRFN3-low versus LRFN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN3→partner) and Y-score (partner→LRFN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.160	+2.000	.011	.032	3	2
UCEC	ATM →	-0.596	-2.700	.003	.006	3	2
UCEC	ER-alpha_pS118 →	-0.376	-2.000	.020	.032	3	1
UCEC	MEK1 →	+0.585	+3.584	<.001	.002	3	1
UCEC	NDRG1_pT346 →	+0.584	+2.000	.008	.032	3	1
UCEC	Notch1 →	+0.228	+2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RAD51 by LRFN3 expression — UCEC

Explore this box plot interactively →