LRFN3

Across TCGA cell cohorts, LRFN3 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRFN3-associated genes across cancer lineages are GCAT, IL7, and SNX14. Each is linked with LRFN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRFN3-to-partner and partner-to-LRFN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by LRFN3-low versus LRFN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN3→partner) and Y-score (partner→LRFN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.175	+3.169	.003	.009	3	1
LARGE_INTESTINE	IL7 →	+0.793	+3.451	.005	.002	3	1
LARGE_INTESTINE	SNX14 →	+0.528	+3.169	.002	.009	3	1
LARGE_INTESTINE	C9orf72 →	+0.678	+3.364	.008	.002	3	1
LARGE_INTESTINE	HAUS1 →	+0.666	+3.451	.006	.002	3	1
LARGE_INTESTINE	FAM102B →	+0.934	+3.169	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

GCAT by LRFN3 expression — LARGE_INTESTINE

Explore this box plot interactively →