LRFN2

Across TCGA cell cohorts, LRFN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,625 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LRFN2-associated GO terms across cancer lineages are Negative regulation of T-helper cell differentiation, Mitotic DNA damage checkpoint signaling, and Regulation of calcium ion transport into cytosol. Each is linked with LRFN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both LRFN2-to-partner and partner-to-LRFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of T-helper cell differentiation grouped by LRFN2-low versus LRFN2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN2→partner) and Y-score (partner→LRFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of T-helper cell differentiation →	-0.146	-0.408	<.001	<.001	3	6
BONE	Mitotic DNA damage checkpoint signaling →	+0.102	+1.066	<.001	.003	3	6
BONE	Regulation of calcium ion transport into cytosol →	-0.211	-1.042	<.001	.001	3	5
BONE	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	-0.194	-1.595	<.001	<.001	3	5
BONE	Zymogen activation →	-0.247	-1.010	<.001	.002	3	5
BONE	Negative regulation of alpha-beta T cell activation →	-0.133	-1.529	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,625 associations by consensus.

Negative regulation of T-helper cell differentiation by LRFN2 expression — BREAST

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