LRFN2

Across TCGA cell cohorts, LRFN2 mutation is significantly associated with the RNA expression of many other genes, with 483 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRFN2-associated genes across cancer lineages are ECHS1, CTC1, and TAF15. Each is linked with LRFN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRFN2-to-partner and partner-to-LRFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECHS1 grouped by LRFN2-low versus LRFN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN2→partner) and Y-score (partner→LRFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECHS1 →	+0.738	+3.321	<.001	.003	3	2
LARGE_INTESTINE	CTC1 →	+0.690	+3.502	.008	.001	3	2
LARGE_INTESTINE	TAF15 →	+0.614	+3.087	.001	.006	3	2
KIDNEY	PAX4 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	OR2F2 →	+0.020	+5.000	<.001	.005	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.027	+2.951	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 483 associations by consensus.

ECHS1 by LRFN2 expression — LARGE_INTESTINE

Explore this box plot interactively →