LRFN1

Across TCGA patient cohorts, LRFN1 mutation is significantly associated with the RNA expression of many other genes, with 981 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LRFN1-associated genes across cancer lineages are OR10C1, MIR1245A, and RNU4ATAC12P. Each is linked with LRFN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRFN1-to-partner and partner-to-LRFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10C1 grouped by LRFN1-low versus LRFN1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN1→partner) and Y-score (partner→LRFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR10C1 →	+0.017	+4.247	<.001	.007	3	3
COAD	MIR1245A →	+1.129	+4.103	<.001	<.001	3	3
SKCM	RNU4ATAC12P →	+0.387	+2.560	<.001	<.001	3	3
SKCM	L2HGDH →	+0.527	+3.478	.004	.002	3	3
SKCM	MIR619 →	+0.445	+1.986	<.001	.007	3	3
STAD	MICOS10P4 →	+0.171	+2.784	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 981 associations by consensus.

OR10C1 by LRFN1 expression — CESC

Explore this box plot interactively →