LRFN1

Across TCGA patient cohorts, LRFN1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRFN1-associated genes across cancer lineages are Notch1, JNK2, and MEK1. Each is linked with LRFN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRFN1-to-partner and partner-to-LRFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by LRFN1-low versus LRFN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN1→partner) and Y-score (partner→LRFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.163	+3.331	.012	.005	3	3
UCEC	JNK2 →	+0.311	+3.026	<.001	.018	3	2
UCEC	MEK1 →	+0.706	+3.700	<.001	.001	2	3
UCEC	VHL →	-1.217	-2.584	<.001	.011	3	2
UCEC	p62 Lck ligand →	+0.505	+3.331	<.001	.005	3	1
UCEC	SLC1A5 →	-0.420	-2.314	.049	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Notch1 by LRFN1 expression — UCEC

Explore this box plot interactively →