LRFN1

Across TCGA cell cohorts, LRFN1 mutation is significantly associated with the RNA expression of many other genes, with 475 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRFN1-associated genes across cancer lineages are SH3GL2, PIGL, and BCAS2. Each is linked with LRFN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRFN1-to-partner and partner-to-LRFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by LRFN1-low versus LRFN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRFN1→partner) and Y-score (partner→LRFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+0.945	+2.252	.002	.004	3	2
LARGE_INTESTINE	PIGL →	+0.708	+3.321	.001	.002	3	2
LARGE_INTESTINE	BCAS2 →	+0.591	+3.850	<.001	<.001	3	2
LARGE_INTESTINE	ATG4C →	+0.589	+3.850	<.001	<.001	3	2
LARGE_INTESTINE	METTL16 →	+0.431	+2.043	.009	.008	3	2
LARGE_INTESTINE	BBS7 →	+0.488	+2.043	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 475 associations by consensus.

SH3GL2 by LRFN1 expression — LARGE_INTESTINE

Explore this box plot interactively →