Across TCGA patient cohorts, LRCH3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,728 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LRCH3-associated genes across cancer lineages are ENTPD1, IL2RA, and LGALS1. Each is linked with LRCH3 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRCH3-to-partner and partner-to-LRCH3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH3→partner) and Y-score (partner→LRCH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ENTPD1 →	+0.493	+0.198	.003	.001	3	5
BRCA	IL2RA →	+0.693	+0.156	<.001	<.001	3	5
BRCA	LGALS1 →	+0.953	+0.207	<.001	<.001	3	4
OV	CCDC88A →	+0.924	+0.436	<.001	<.001	3	4
OV	WIPF1 →	+0.827	+0.397	.001	<.001	3	4
LUAD	S1PR4 →	+0.615	+0.143	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,728 associations by consensus.

Exploration

LRCH3 survival (RNA) · tumor vs normal (RNA) · all LRCH3 data types