Across TCGA patient cohorts, LRCH3 mutation is significantly associated with the RNA expression of many other genes, with 1,886 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRCH3-associated genes across cancer lineages are SEPTIN14P24, RNA5SP147, and MIR548A3. Each is linked with LRCH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH3-to-partner and partner-to-LRCH3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH3→partner) and Y-score (partner→LRCH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SEPTIN14P24 →	+0.542	+4.588	<.001	.008	3	2
BRCA	RNA5SP147 →	+0.242	+5.324	<.001	.003	3	2
CESC	MIR548A3 →	+0.361	+3.411	<.001	.009	3	2
COAD	POM121L1P →	+0.014	+4.418	.002	.008	3	2
UCEC	PARD6A →	+0.618	+2.070	.001	.001	3	2
UCEC	MPG →	+0.495	+2.930	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,886 associations by consensus.

Exploration

LRCH3 survival (RNA) · tumor vs normal (RNA) · all LRCH3 data types