Across TCGA cell cohorts, LRCH3 mutation is significantly associated with the RNA expression of many other genes, with 275 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRCH3-associated genes across cancer lineages are THEG, HRG, and PRKAG3. Each is linked with LRCH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH3-to-partner and partner-to-LRCH3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH3→partner) and Y-score (partner→LRCH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	THEG →	+0.246	+3.769	<.001	.008	3	1
BLOOD_Leukemia	HRG →	+0.341	+3.855	<.001	.007	3	1
BLOOD_Leukemia	PRKAG3 →	+0.035	+3.551	<.001	.009	3	1
BLOOD_Leukemia	MMP20 →	+0.048	+3.705	<.001	.007	3	1
BLOOD_Leukemia	SPATA19 →	+0.018	+4.984	<.001	.002	3	1
BLOOD_Leukemia	WFDC12 →	+0.194	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 275 associations by consensus.

Exploration

LRCH3 survival (RNA) · tumor vs normal (RNA) · all LRCH3 data types