LRCH2

Across TCGA patient cohorts, LRCH2 mutation is significantly associated with the RNA expression of many other genes, with 4,562 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRCH2-associated genes across cancer lineages are RNU6-1127P, RNA5SP419, and RNA5SP113. Each is linked with LRCH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRCH2-to-partner and partner-to-LRCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1127P grouped by LRCH2-low versus LRCH2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH2→partner) and Y-score (partner→LRCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-1127P →	+0.126	+4.020	<.001	.009	3	3
UCEC	RNA5SP419 →	+0.352	+1.419	<.001	.002	3	3
COAD	RNA5SP113 →	+0.214	+3.973	<.001	.008	3	3
UCEC	RNA5SP412 →	+0.346	+1.309	<.001	.005	3	2
BRCA	EGLN3-AS1 →	+0.248	+3.552	.001	.002	3	2
READ	CDK4P1 →	+0.148	+5.421	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,562 associations by consensus.

RNU6-1127P by LRCH2 expression — CESC

Explore this box plot interactively →