LRCH2

Across TCGA patient cohorts, LRCH2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRCH2-associated genes across cancer lineages are p70-S6K_pT389, ASNS, and Caspase-7-cleavedD198. Each is linked with LRCH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH2-to-partner and partner-to-LRCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by LRCH2-low versus LRCH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH2→partner) and Y-score (partner→LRCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.172	-1.736	<.001	.005	3	2
UCEC	ASNS →	+0.316	+1.263	.001	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.519	+1.604	.001	.002	3	2
UCEC	c-Met_pY1235 →	+0.045	+1.272	.024	.010	3	2
UCEC	eIF4E →	+0.202	+2.432	<.001	<.001	3	1
UCEC	JNK2 →	+0.155	+1.459	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p70-S6K_pT389 by LRCH2 expression — UCEC

Explore this box plot interactively →