LRCH2

Across TCGA cell cohorts, LRCH2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRCH2-associated genes across cancer lineages are MDGA2, GJD2, and OR10Q1. Each is linked with LRCH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH2-to-partner and partner-to-LRCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDGA2 grouped by LRCH2-low versus LRCH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH2→partner) and Y-score (partner→LRCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MDGA2 →	+0.118	+3.854	.007	.006	3	1
LARGE_INTESTINE	GJD2 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR10Q1 →	+0.116	+3.920	<.001	.005	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	DYNAP →	+0.071	+4.867	.002	.009	3	1
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MDGA2 by LRCH2 expression — LARGE_INTESTINE

Explore this box plot interactively →