LRCH1

Across TCGA pan-cancer cohorts, LRCH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRCH1 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LRCH1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LRCH1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where LRCH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.934	0.418	<.001	65	view →
HNSC	DFS	Median	All	0.697	0.859	.005	21	view →
PDAC	DFS	Median	IV	0.199	0.680	.004	9	view →
LSCC	DFS	Median	II,III,IV	0.842	0.989	.028	3	view →
UCEC	OS	Median	All	0.966	0.862	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LRCH1–CCRCC (DFS)

Open the CCRCC breakdown →